Program

Oral Communication 1: 02.019 Effects of the lithium treatment on early stage of Sporadic Alzheimer’s (sAD) Disease in male rats. Lima, TF, Kanazawa LKS, Fernandes, SMA, Vital, MABF. UFPR, Pharmacology Dept, Brazil

Oral Communication 2: 02.024 Integrated network pharmacology, molecular docking, and cellular analysis of beta-ciclodextrin complexed 1,8-cineole in Parkinson´s Disease. Araújo-Monteiro L¹, Carvalhinho-Lopes PS¹, Soares-Silva B¹, Donzelli NIZ¹, Quintans-Junior LR², Rando DG³, Ribeiro AM¹ ¹Unifesp-Baixada Santista, PPG in Bioproducts and Bioprocesses, Brazil; ²UFS, PPG in Pharmaceutical Sciences, Brazil; ³Unifesp-Diadema, PPG in Pharmaceutical Sciences; Brazil.

Oral Communication 1: 04.024 Evaluation of the effects of docosahexaenoic acid (dha) and dha-loaded nanocapsules on the endothelium in in vitro and in vivo models. Gomes-Reis GLS¹, Moraes BPT², Saraiva JSG², Cunha CMC¹, Ferreira-Costa M¹, Santos FS³, Ferreira AM¹, Bozza PT¹, Castro-Faria-Neto HC¹, Ferrarini SR⁴, Silva AR¹, Gonçalves-de-Albuquerque CF^1,2. ¹IOC-Fiocruz, Immunopharmacology Lab and PPG in Cellular and Molecular Biology, Rio de Janeiro, Brazil; ²Unirio, Immunopharmacology Lab and PPG in Molecular and Cellular Biology, Rio de Janeiro, Brazil; ³UFF, PPG, in Neuroscience, Niterói, Brazil; ⁴UFMT-Sinop, PPG Health Sciences, Brazil

Oral Communication 2: 04.042 Ouabain improves pulmonary function in a murine model of mixed asthma. Ribeiro, MR¹, Souza-Lima T¹, Siena A¹, Francelino-Alves V¹, Melhado IV¹, Fernandes PH¹, de Sá Lima L¹, Andreotti DZ¹, Oliveira MA¹, Leite J², Moriya HT³, Rodrigues-Mascarenhas S⁴, Tavares-de-Lima W¹, Scavone C^{1 1}ICB-USP, Dept. of Pharmacology, SP, Brazil; ²ICB-UFG, Dept. of Pharmacology, GO, Brazil; ³EP-USP, Dept. of Telecommunication and Control Engineering, SP Brazil; ⁴UFPB, Dept of Cell and Molecular Biology, João Pessoa, PB, Brazil

Oral Communication 1: 14.005FR Three-dimensional cold porcelain modeling as a pedagogical tool for human physiology education. Nóbrega VC, Cruz JC UFPB, Dept. of Biotechnology, PPG Physiological Sciences, Brazil

Oral Communication 2: 13.005 Developing scientific literacy through neuropharmacology education and research training in middle grade students. Fonseca RD¹, Costa SF², Machado LHR², Nin MS³, Barros HMT^{4 1}UFCSPA, Lab. Neuropsychopharmacology, PPG Health Sciences: Pharmacology and Toxicology, Brazil. ²UFCSPA, Lab. Neuropsychopharmacology, Brazil. ³UFCSPA, Dept. of Pharmacosciences, Lab. Neuropsychopharmacology, Brazil. ⁴UFCSPA, Dept. of Pharmacosciences, Lab. Neuropsychopharmacology, PPG Health Sciences: Pharmacology and Toxicology, Brazil.

Oral Communication 1: 06.050 Mineralocorticoid receptors promote Th17 polarization in lymph nodes while IL-17RA drives pro-inflammatory phenotypic changes in perivascular adipose tissue during obesity. Dourado TMH¹, Pimenta GF¹, Elias-Oliveira J², Rodrigues VF², Fazan-Junior R³, Sartori DC², Tirapelli CR^{4 1}FMRP-USP, Depto Farmacologia; ²FMRP-USP, Depto Bioquímica e Imunologia, ³FMRP-USP, Depto Fisiologia; ⁴FCFRP-USP, Depto Ciências BioMoleculares

Oral Communication 2: 06.038 Distinct glycation modifications of Type I collagen differentially regulate platelet reactivity. Fróes RBL, Silva BS, Gaspar RS FCM-Unicamp, PPG Farmacologia, Lab Matriz Extracelular, Brasil.

Oral Communication: 10.047 Apoptosis induction by the angucycline saquayamycin B1 in melanoma cells: involvement of oxidative stress and MAPK signaling. Silvestre GFG¹, Souza RRM¹, Marques KKG¹, Dantas MM¹, Duarte SS¹, Castro IO¹, Ramalho IGS¹, Queiroga LM², Araújo YKO², Cibulski S³, Nascimento IJS⁴, Moura RO⁴, Tavares JF⁵, Gonçalves JCR¹, Sobral MV¹. ¹UFPB, ONCOFAR, PPG of Bioactive Natural and Synthetic Products, Brazil. ²UFPB, ONCOFAR, Undergraduate in Pharmacy, Brazil. ³UFRN, FACISA, Faculty of Health Sciences, Brazil. ⁴UEPB, LDSF, PPG of Pharmaceutical Sciences, Brazil. ⁵UFPB, LMCA, PPG of Bioactive Natural and Synthetic Products, Brazil.

Oral Communication 2: 10.035 VLA-4 integrin and VEGFR blockade regulates B16F10 melanoma adhesion, migration and proliferation. Cavalcante KDM¹, Cavalcante MLS¹, Paixão MS², Lima KFN¹, Monte SJH³, Pereira EM³, Guimarães PPG⁴, Sousa JMC⁵, Ferreira PMP^1,6,7, Dittz D^{1,5 1}UFPI, Graduate Program in Pharmacology, Brazil; ²UFPI, School of Pharmacy, Brazil; ³UFPI, Immunogenetics and Molecular Biology Lab (LIB), Brazil; ⁴UFMG, Dept Biophysics and Physiology, Brazil; ⁵UFPI, Dept Biochemistry and Pharmacology, Brazil; ⁶UFPI, Experimental Cancerology Lab (LabCancer), Brazil; ⁷UFC, Experimental Oncology Lab (LOE), Drug Development Research Center (NPDM), Brazil.

Oral Communication 1: 03.004 In silico and in vivo evaluation of gabaergic neurotransmission in the anxiolytic-like effect of the thiophenic derivative 6CN07. Mendes LM, Naves FB, Almeida JVM, Pereira CHL, Alves HAR , Alves ARS, Teixeira JL, Neri LCD, Barbosa NMMV, Martins AMO, Oliveira LN, Soares MFS, Silva PR, Monteiro AB, Felipe CFB UFPB, Psychopharmacology Lab, Brazil

Oral Communication 2: 03.032 Effects of antagonism of orexin receptors, administered during the acquisition phase, on alcohol preference in the two-bottle choice model in swiss male mice. Silva VS¹, Costa RCA¹, Costa EF¹, Ferreira KR¹, Santos RS², Carneiro DM², Zhang Y³,Marinho ELAM4, Marinho EAV², Lima AJO², Berro LF5. ¹UESC, PPG Health Sciences, Brazil, ²UESC, Dept Health Sciences, Brazil, ³Research Triangle Institute, USA, ⁴UESC, Dept Biological Sciences, Brazil, ⁵University of Mississippi Medical Center, USA

Oral Communication 1: 10.012FR Maternal protein restriction reprograms placental proteomic networks and ultrastructure: insights into early developmental adaptation. Barata LA¹, Fioretto MN¹, Magosso N¹, Ferreira MR², Maciel FA¹, Felipe VAA¹, Ribeiro IT¹, Dos Santos DC¹, Justulin LA¹ ¹IBB-Unesp-Botucatu, Dept Cellular and Molecular Biology, PPG in General and Applied Biology, Brazil. ²Unesp-Botucatu, School of Medicine, Experimental Research Unit - Unipex, Molecular Genetics and Bioinformatics Lab, Brazil.

Oral Communication 2: 10.010FR Effects of moderate-continuous training on cardiac mitochondrial bioenergetics and redox status in rats subjected to early-life overnutrition. Silva JTA, Fernandes MSS, Correia-Filho RC, Melo TSM, Fernandes MP, Lagranha CJ UFPE, Graduate Program in Nutrition, Physical Activity, and Phenotypic Plasticity, Brazil; UEFS, Brazil

Oral Communication 3: 10.013FR Early life protein restriction impairs glp-1-induced insulin secretion despite increased intra-islet GLP-1 Production. Oliveira KM¹, Silva-Junior JA², Carvalho MS¹, Bem KCP¹, Barbosa HCL¹, Carneiro, EM^{1 1}Unicamp, Obesity and Comorbidities Research Center (OCRC), Brazil; ²Universidad Miguel Hernández, Instituto de Investigación en Biotecnología y Salud

Oral Communication 1: 04.062 SIRT2 Inhibition attenuates neuroinflammation induced by Klebsiella pneumoniae infection. Ferreira-Costa M¹, Thiele E², Almeida MAP², Santos, FS², Gomes-Reis, GLS¹, Cunha, CMC¹, Ferreira, A¹, Bozza PT¹, Castro-Faria-Neto HC¹, Gonçalves-de Albuquerque CF^2,3, Silva AR¹ ¹IOC-Fiocruz, Immunopharmacology Lab, PPG in Cellular and Molecular Biology, Rio de Janeiro, Brazil, ²UFF, PPG in Neuroscience, Rio de Janeiro, Brazil, ³Unirio, Immunopharmacology Lab, PPG in Molecular and Cellular Biology, Rio de Janeiro, Brazil

Oral Communication 2: 04.060 Graft-versus-host disease promotes central neuroinflammation and glutamatergic dysfunction associated with anxiety-like behavior in mice. Linhares AFS¹, Lima ALD¹, Berg BB¹, Rocha ES², Ruggio GMF¹, Sales MA², Silva MCM¹, Oliveira NFM³, Campos ZDT¹, Vieira LB⁴, Machado FS⁵, Pinho V6, Teixeira MM⁵, Oliveira ACP⁴, Romero MGMC⁴. ¹UFMG, Graduate Program in Pharmacology and Physiology, Brazil; ²UFMG, Undergraduate student in Biomedical Sciences, Brazil; ³UFMG Graduate Program in Biochemistry and Immunology, Brazil; ⁴UFMG Dept Physiology and Pharmacology, Brazil; ⁵UFMG, Dept Biochemistry and Immunology, Brazil; ⁶UFMG, Dept Morphology, Brazil.

Oral Communication 3: 04.026 Chronic kidney disease and cognitive impairment from the perspective of neuroinflammation: evaluation of the exposure of healthy astrocytes to uremic serum. Custodio GT¹, Russo FB², Beltrão PCB², Kawamoto EM ^{1 1}USP, Dept Pharmacology, Brazil, ²USP Dept Microbiology, Brazil, PPG Functional and Molecular Biology, Brazil.

Oral Communication 1: 09.086 The triterpene friedelin attenuates TGF-β-Induced EMT in NCI-H292 lung cancer cells and upregulates TIMP3 expression. Almeida JH¹, Bodin A², Victoni T²³, Barreto EO¹, Lagente V², Ferro JNS¹ ¹UFAL, Lab Biologia Celular, Maceió, AL, Brasil. ²Université de Rennes, Inserm, Inrae, NuMeCan (Nutrition, Métabolismes et Cancer), Rennes, France. ³Université de Lyon, VetAgro Sup, Lyon, France.

Oral Communication 2: 09.059 Caulerpin modulates the calcineurin-NFAT signaling AXIS and attenuates T-cell activation in human peripheral blood mononuclear cells. Santos-Junior SS, Dos Santos JSP, Correia AGV, Oliveira VS, Silva DKC, Souza CVC, Santos-Filho OA, Martinez ST, Soares MBP, Meira CS Fiocruz-BA, Salvador, UNEB, Salvador, SENAI CIMATEC-BA, Salvador, UFRJ-RJ, Rio de Janeiro FURG-RS, Rio Grande do Sul.

Oral Communication 1: 05.030 Advanced glycation end-products promote neuronal dysfunction and neurodegeneration in sensory-like neurons and sensorimotor organoids. Silva GSA¹, Bufalo MC^3,4, Chudzinski-Tavassi AM^3,4, Pereira JD², Zambelli VO^1,3. ¹IBu, Lab Pain and Signaling, Brazil. ²University of Alabama at Birmingham, Dept Neurology, USA. ²IBu, Center of Excellence in New Target Discovery, Brazil. ⁴IBu, Innovation and Development Center, Brazil.

Oral Communication 2: 05.009 Antinociceptive effects of MSCs and MSC-EVs are associated with CXCR2 pathway in neuropathic pain mice model. Velozo ACL¹, Opretzka LC², Jesus MVAC¹, Cruz ABO¹, Santos MGS³, Santos GC³, Soares MBP³, Villarreal CF¹. ¹UFBA, School of Pharmacy, Salvador, Brazil; ²SENAI-CIMATEC, Salvador, Brazil; ³Fiocruz-BA, Salvador, Brazil

Oral Communication 1: 12.035 In silico Evaluation of LOE2208 and Its derivatives reveals predicted interactions with tubulin protein and suitable ADMET profiles. Lima JM^1,2, Da Costa RF^3,4, Bezerra EM^3,4, Viera-Neto JB^1,2, Falcão JS^5,6, Lapa DP^5,6, Costa PRR^5,6, Caleffi GS^5,6, Pessoa C^1,2. ¹UFC, Lab. of Experimental Oncology, Drug Research and Development Center, Brazil; ²UFC PPG Pharmacology, Brazil; ³UFERSA, Lab. of Computational Physics, Brazil; ⁴UFERSA, PPG Science and Engineering of Materials, Brazil; ⁵UFRJ, Lab. of Bioorganic Chemistry, Research Institute of Natural Products Walter Mors, Brazil; ⁶UFRJ, PPG Chemistry of Natural Products, Brazil.

Oral Communication 2: 04.054 Role of estradiol/GPER signaling in the sickness response during systemic inflammation. Costa RA, Schneider RC, Santos MO, Pereira V, Borges AP, Schneider VMM, Alencar ST, Baggio DF, Zampronio AR. UFPR, Inflammation and Fever Lab, Dept Pharmacology, Brazil.

Oral Comunication 3: 12.028 In vivo and in vitro anti-inflammatory activity of CBD-derived terpene-cinnamoyl-acyl-hydrazone molecules. Paiva JPB¹, Lontra ACP¹, Souza, MK², Franco GRR ², Gontijo VS ², Viegas-Jr C², Fernandes PD¹ ¹ICB-UFRJ, Program of Reserch and Drug Discovery, Lab. of Pharmacology of Pain and Inflammation, Brazil; ²UNIFAL, Lab. of Research in Medicinal Chemistry, Brazil.